The description of the protein encoded in this ORF: death-associated protein 5
The translational frameshift (ribosome slippage) involved: 0
The ribosome read-through involved: no
The alternative forms of this protein occur by the alternative initiation of translation: not tested
The ORF absolute position (the base range includes START and STOP codons or their equivalents): 418-3141
IRESite annotation is based on NM_001418.3 sequence. The record NM_001418.1 contained CDS between positions
307-3030 which matched the comments in the article by Henis-Korenblit et al. (2000) that the 5'-UTR was about
300 bp long and in Imataka et al. (1997) that the GUG-initiated CDS encodes 907 aa residues. A sequence of the
cloned cDNA was shown in Figure 2 in Levy-Strumpf et al. (1997) and aligns with this RefSeq sequence since its
position 127 (thus positions 1-7 shown in the Figure 2 do not have a counterpart). The sequence of p97/DAP5
published by Imataka is in AF104913 (GI:3941723).
The forward primer described in Henis-Korenblit et al. (2000) aligns well to both these RefSeq sequences while
the reverse primer mismatches in several positions. EST sequences confirm this NM_001418.3 sequence since
position 81 downstream while such ESTs begin at that position (GI:83041139).
Although RefSeq annotates this sequence as eIF4G2 we removed this gene name from this record because the DNA
sequence differs from both eIF4GI and eIF4GII. Probably because Shaughnessy et al. (1997) called this 907 aa
residues spanning CDS eIF4G2.
DAP5/p86 is a caspase cleaved DAP5 protein form. It has been shown that transient over-expression of the
DAP5/p86 truncated protein form supports internal ribosome entry site-mediated translation of DAP5, Apaf-1,
c-Myc and XIAP (so-called death proteins).